The isometric game-form is a classic art that has seen numerous iterations over the years and still has a solid base of advocates - albeit largely from the retro camp.
I've been a fan since the Ultimate Play the Game days - the Filmation classics Alien8 and Knight Lore - and Bernie Drummond and Jon Ritman nailed home my love for isometric with the awesome Batman and Head Over Heels (there's an interesting little interview with Jon Ritman here - not the best sound but nice to hear details from the early days).
So I thought I'd put some links to some recent retro remake classics of Knight Lore and Head Over Heels.
Both are great achievements, in my opinion, and they've brought the whole kit and caboodle from the originals - including the painful control mechanism and pixel-perfect gameplay...
Download the Knight Lore remake here
Download the Head Over Heels remake here
Comments
How could they spell his name wrong in that video? 
But anyway, I've always liked isometric graphics too. I guess in the early days it was a good cheap method of attaining 3D while still using sprites without any complicated 3D maths, while now it's more of a design choice for those who still prefer the pixel art style. I still remember playing 3D Ant Attack on the Spectrum when it came out in the early 80s, and which was probably the first ever isometric computer game. And then I was meticulously copying the sprites from Knight Lore and Alien 8 from magazines onto graph paper to try and find out how they were done.
I remember one of my most early game programming attempts was to make a game just like LandStalker on the Megadrive. (In VB6 using the windows GDI) That was just over 10 years ago now.
I didn't get much further than displaying an Isometric map, but it was good fun.